williamson ether synthesis of phenacetin lab report

After a reaction is completed, the solution often times does not only contain the desired product, but also undesired byproducts of the reaction, unreacted starting material(s). Orgo lab Orgo lab Preview text Williamson Ether Synthesis: Preparation of Phenacetin from Acetaminophen Partners: Victor, Zahra April 12, 2016 Methods and Background The goal of this lab is to use the Williamson ether synthesis and prepare a phenacetin. Introducing Textbook Solutions. Williamson Ether Synthesis is a two-step process. The extraction removes the target compound from an impure matrix, the washing, removes impurities from the target compound. This means there needs to be a strong, nucleophile, a good unhindered leaving group, and a polar aprotic solvent. In this lab, the Williamson ether synthesis was used to convert acetaminophen to phenacetin. The acetaminophen, acted as the nucleophile and the Iodoethane was the electrophile. Obtain 360 mg of acetaminophen and transfer into a dry 25-mL round-bottom flask (RBF). Add a stir bar, 560 mg of K 2CO 3 (ground if necessary), 6.0 mL of acetonitrile (CH 3CN), and lastly 0.56 mL of ethyl iodide. After the creation acetaminophen, the. Figure 1: Acetaminophen to Phenacetin Reaction. One way to make ethers is to use, the Williamson Ether synthesis which is where an alcohol is deprotonated using a base, and a. primary alkyl halide is added to the reaction. Background and methods: In this lab, Phenacetin was prepared by the Williamson ether synthesis using acetaminophen and iodoethane in the presence of a base. After the creation acetaminophen, the actual mass that was collected was 1.477g and the percent yield for the synthesis was 71.06%. These compounds, have to be removed in the process of isolating the pure product. The alcohol that was used was acetaminophen, the alkyl halide that was used Iodoethane and the ether that was formed was Phenacetin. Williamson Ether Synthesis: Preparation of Phenacetin from Acetaminophen. The alcohol is first converted to an alkoxide, by using a strong base and then the alkoxide reacts with a primary alkyl halide through a SN2, In this experiment, a SN2 reaction took place. The washing and the extractions are responsible for 2 different parts of the, experiment. Course Hero is not sponsored or endorsed by any college or university. Phenacetin is prepared by taking Acetaminophen, which is an active ingredient in, Tylenol, and mix it with iodoethane in the presence of a base. Synthesis of Phenacetin from Acetaminophen (Prepared in Lab by Acetylation of -Aminophenol) through Williamson Ether The literature and experimental melting point of the acetaminophen are within close range of each other. In this lab, students were able to use Williamson ether synthesis, which follows the S N 2 mechanism to convert acetaminophen into phenacetin. View Lab Report - Lab report.docx from CHEM 212 at Ramapo College Of New Jersey. Lab 6 report - Lab 6 Williamson Ether Synthesis of Phenacetin Sara Howard TA Cadnel Sly Detchou March 31st 2015 Abstract In this experiment the, 6 out of 7 people found this document helpful, Lab 6: Williamson Ether Synthesis of Phenacetin, In this experiment, the Williamson ether synthesis of Phenacetin was done by combining. View Lab Report - Lab 6 report from CHE 202 at SUNY Buffalo State College. The phenolic hydrogen is sufficiently acidic to be deprotonated by potassium carbonate to allow the reaction to occur. The theoretical yield for the reaction was 1.54 g, and the experimental yield was 0.56g. With the theoretical and experimental yield obtained, the percent yield was calculated and found to be 36.36 %. For phenacetin, the actual, mass collected 0.703g and the percent yield was 91.53% and the literature melting point is, 134.5ºC and the experimental melting point is between 134.5 to 135.5ºC. The reason potassium carbonate is used is to be able to deprotonate the phenols hydrogen. Attach a microscale water-cooled condenser and, Washing is also used as a step in the, recrystallization procedure to remove the impurity adhering to the crystal surface, Many extractions are based on acid-base chemistry. The potassium carbonate was. Orgo lab Preview text Hanna Thomson Lab 10 Erica Tuesday 8am Williamson Ether Synthesis: Preparation of Phenacetin from Acetaminophen Methods and Background The purpose of this experiment was to prepare phenacetin by Williamson ether synthesis using acetaminophen and iodoethane as our starting materials, by deprotonation of the alcohol with a strong base potassium … Please sign in or register to post comments. By the end of the lab, the phenacetin went through melting point determination to prove whether it was a pure product. actual mass that was collected was 1.477g and the percent yield for the synthesis was 71.06%. Lab 6: Williamson Ether Synthesis of Phenacetin Sara Howard TA: Cadnel Sly Detchou March 31st, 2015 Abstract In this Week 1 – Synthesis of Phenacetin, Williamson Ether Synthesis Reaction Set Up. Most of the extractions are performed using, , in this experiment, 5% NaOH is utilized. The literature and experimental melting point of the acetaminophen are within close range of, each other. The atom economy that, was calculated for the synthesis of phenacetin is 0.46289, and this value produced a reaction, In this lab, the main goal was to use the Williamson ether synthesis, this method. This preview shows page 1 - 3 out of 10 pages.

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